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Coupling of Excitation and Neurogenesis in Neural Stem/Progenitor Cells
Stanford Reference:
01-094
Abstract
Stanford Researchers have discovered a manipulation that specifically promotes neurogenesis of differentiating neural stem/progenitor cells (NPCs). This occurs through the coupling of excitation, sensed via L-type Ca2+ channels and NMDA receptors, to neurogenesis in proliferating post-natal NPCs both in vitro and in vivo. These excitatory stimuli increase both the fraction of NPC progeny that are neurons as well as total neuron number. Importantly, these nascent neurons have normal functional properties including the formation of functional synaptic connections.
Applications
Potential therapies for patients with neurological and psychiatric disorders
Screening methods to identify compounds that induce neurogenesis in culture models
In vitro screening methods to identify compounds that act directly on excitation sensors or that influence downstream markers
Advantages
Promotes formation of neurons, and synapse formation in addition to the other influences exerted by typical differentiation medium
Patient-specific
Publications
Published patent application no.
US-2005-0267011-A2
K. Deisseroth, R. Malenka.
GABA Excitation in the Adult Brain: A Mechanism for Excitation- Neurogenesis Coupling.
Neuron 2005, Volume 47, Issue 6, Pages 775-777.
K. Deisseroth, S. Singla, H. Toda, M. Monje, T. Palmer, R. Malenka.
Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells.
Neuron 2004, Volume 42, Issue 4, Pages 535-552.
Innovators & Portfolio
Karl Deisseroth
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Robert Malenka
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Patent Status
Published Application: 20050267011
Issued : 7,670,838 (USA)
Date Released
10/8/2020 12:00
Licensing Contact
Evan Elder, Senior Licensing Associate
650-725-9558 (Mobile)
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Related Keywords
LS: cell therapy: stem cell
MD: neurology
LS: research tool: cell line
stem cells
01-094
therapeutic
research tool
