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Reporter cell line for TGFbeta signaling
Stanford Reference:
07-069
Abstract
Stanford researchers have developed a cell line (MFB-F11) that can be used for an easy, sensitive, and specific bioassay to study the biological functions of Transforming Growth Factor-beta (TGF-beta). TGF-beta regulates key biological processes and has been implicated in many diseases. The MBF-F11 cells can be used for basic research or for screening drugs that target the TGF-beta signaling pathway. In addition, assays can be performed on a variety of biological samples, including cell culture supernatants, body fluids, or tissue homogenates, with or without prior denaturation of TGF-beta.
Applications
Drug screening
- for compounds that target the TGF-beta signaling pathway
Research
- basic research on the effects of TGF-beta on biological processes
Advantages
Rapid
Sensitive
- assay detected as little as 1pg/ml TGF-beta1
Specific
- MFB-F11 cells were highly induced by TGF-beta, TGFbeta2 and TGF-beta3, but did not show induction with related family members or trophic factors
Simple
- MFB-F11 cells can detect and quantify TGF-beta from biological specimens with or without prior denaturation of TGF-beta
Publications
Tesseur I, Zou K, Berber E, Zhang H, Wyss-Coray T.,
"Highly sensitive and specific bioassay for measuring bioactive TGF-beta."
BMC Cell Biol.
2006 Mar 20;7:15.
Web Site
Wyss-Coray Lab
Innovators & Portfolio
Anton Wyss-Coray
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Date Released
6/30/2015 12:00
Licensing Contact
Brenda Martino, Biological Materials Specialist
(650) 725-9119 (Direct)
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Related Keywords
alzheimer's disease
atherosclerosis
blood
cancer
cardiovascular
immune
infectious
MD: neurology
rheumatoid arthritis
stroke
fibrosis
LS: research tool: cell line
screening: cellular assay
screening: screen
signaling pathways
research tool
screening