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Reporter cell line for TGFbeta signaling


Stanford Reference:

07-069


Abstract


Stanford researchers have developed a cell line (MFB-F11) that can be used for an easy, sensitive, and specific bioassay to study the biological functions of Transforming Growth Factor-beta (TGF-beta). TGF-beta regulates key biological processes and has been implicated in many diseases. The MBF-F11 cells can be used for basic research or for screening drugs that target the TGF-beta signaling pathway. In addition, assays can be performed on a variety of biological samples, including cell culture supernatants, body fluids, or tissue homogenates, with or without prior denaturation of TGF-beta.

Applications


  • Drug screening - for compounds that target the TGF-beta signaling pathway
  • Research - basic research on the effects of TGF-beta on biological processes

Advantages


  • Rapid
  • Sensitive - assay detected as little as 1pg/ml TGF-beta1
  • Specific - MFB-F11 cells were highly induced by TGF-beta, TGFbeta2 and TGF-beta3, but did not show induction with related family members or trophic factors
  • Simple - MFB-F11 cells can detect and quantify TGF-beta from biological specimens with or without prior denaturation of TGF-beta

Publications



Web Site


Wyss-Coray Lab

Innovators & Portfolio



Date Released

 6/30/2015 12:00
 

Licensing Contact


Brenda Martino, Biological Materials Specialist
(650) 725-9119 (Direct)
Request Info

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Related Keywords


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