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Pluripotent Cell Lines with Genetic Variations and Methods of Use Thereof
Stanford Reference:
08-264
Abstract
Stanford researchers have developed a method in which induced pluripotent stem cells (iPSCs) can be generated specifically for a disease of interest. In particular, they are able to generate patient-specific iPSCs related to Parkinson's disease or Parkinson's-like disease. The disease-related iPSCs are further differentiated into cell types such as dopaminergic neurons, involved in the disease progression. These differentiated cells are a valuable source for cellular transplantation therapy and as a cellular model for elucidating basic disease mechanisms, screening for therapeutics and for use in diagnostic, prognostic, and theranostic applications.
Applications
Identification of disease mechanisms
Screening for therapeutic agents
Screening and diagnosis of disease
Generation of cell lines with genetic variations of a gene of interest
Advantages
Longer cell life span compared to postmortem samples
Not limited to one type of cell
Can use disease-affected tissue that models fundamental features of the disease at a cellular level
Avoids genetic variations (mutations, copy number variation)
Publications
US patent application 12/459,019:
Pluripotent cell lines and methods of use thereof
Innovators & Portfolio
Blake Byers
Branden Cord
J. William Langston
Ha Nam Nguyen
Theo Palmer
Renee Reijo Pera
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Birgitt Schuele
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Patent Status
Published Application: 20100167286
Published Application: WO2010008486
Published Application: 20140356455
Published Application: 20170114324
Issued : 8,669,048 (USA)
Issued : 9,464,273 (USA)
Issued : 10,233,422 (USA)
Date Released
10/18/2011 12:00
Licensing Contact
Seth Rodgers, Licensing Manager, Life Sciences
617-230-2012 (Mobile)
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Related Keywords
cell transplantation
induced pluripotent stem cells (iPSC)
neural stem cells
Pluripotency genes
Pluripotent cell
stem cell differentiation
stem cell transdifferentiation
stem cell transplantation
stem cell-drug discovery
LS: cell therapy: stem cell
therapeutic
