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NF-AT transcription system for screening of immunosuppressive drugs•The Fgl-5 cell line
Stanford Reference:
91-041
Abstract
NFAT-1 protein bound functional sequences of the long terminal repeat of the HIV Type 1. This LTR is known to be stimulated during early T cell activation. The binding site for this complex activated a linked promoter after transfection into antigen receptor-activated T cells but not other types. These characteristics suggest NFAT-1 transmits signals initiated at the T cell antigen receptor.
Cell Line: 7A6
Cell Line: G1G9
Publications
Science 8 July 1988, Volume 241, pp. 202-205
Science 20 January 1989, Volume 243, pp. 355-361
Science 22 December 1989, Volume 246, pp. 1617-1620
Nature 9 June 1994 Volume 369
Nature 29 August 1991 Volume 352
Melecular and Cellular Biology, Apr. 1988, p 1715-1724
Innovators & Portfolio
Richard Bram
Gerald Crabtree
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Date Released
8/30/1997 12:00
Licensing Contact
Brenda Martino, Biological Materials Specialist
(650) 725-9119 (Direct)
Request Info
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Related Keywords
screening
screening: cellular assay
research tool
LS: research tool: cell line
