Inductive Light Generator (ILG)

Stanford Reference:

06-068

Abstract

This invention is a practical extension of Stanford docket S05-170 (photosensitive proteins Channelrhodopsins) and describes an implantable, light-generating device for the optical stimulation of neural cells. Essentially an optical electrode, this is intended to be a next-generation method providing deep brain stimulation (DBS). Importantly, this neural interface is designed to permit neuron-type-specific modulation. For example, motor fibers might be recruited while leaving immediately adjacent pain fibers undisturbed or excitatory neurons might be harnessed without affecting inhibitory neurons in a region. Targeted, temporally-precise control of neuronal subtypes may enable neuromodulation with fewer side effects and more robust therapeutic efficacy.

Applications

Neurostimulation of photosensitive cells

Advantages

Once implanted, selective activation of the photo-sensitive cells can be achieved non-invasively.

Publications

US Patent Application: 11/651,422
Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature. 2009 Jun 4;459(7247):698-702. Epub 2009 Apr 26.
Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 2009 Jun 4;459(7247):663-7. Epub 2009 Apr 26.
Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning. Science. 2009 May 22;324(5930):1080-4. Epub 2009 Apr 23.
Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical Deconstruction of Parkinsonian Neural Circuitry. Science. 2009 Apr 17;324(5925):354-9. Epub 2009 Mar 19.
Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling." Nature. 2009 Apr 23;458(7241):1025-9. Epub 2009 Mar 18.

Innovators & Portfolio

Karl Deisseroth more technologies from Karl Deisseroth »
David Mishelevich
Michael Schneider more technologies from Michael Schneider »
Feng Zhang more technologies from Feng Zhang »

Patent Status

Date Released

10/8/2020 12:00

Licensing Contact

Evan Elder, Senior Licensing Associate
650-725-9558 (Mobile)
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Related Keywords

MD: neurology: neuromodulation MD: neurology medical devices: minimally/non-invasive MD: orthopedics: prosthetics Coulter medical devices

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